The successful drama Life in a... Metro (2007) marked a turning point in Khan's career, earning him praise and several awards including the Filmfare Award for Best Supporting Actor. He rose to prominence with his portrayal of Paan Singh Tomar in the acclaimed biographical sports drama Paan Singh Tomar (2012), which garnered him the National Film Award for Best Actor and a Filmfare Critics Award for Best Actor. His performance in the BAFTA Award-nominated romance The Lunchbox (2013) earned him universal acclaim by the critics and audiences.
Internationally, he had worked in a number of international projects, such as The Warrior (2001), The Namesake (2006), The Darjeeling Limited (2007), the Academy Award-winning film Slumdog Millionaire (2008), New York, I Love You (2008), The Amazing Spider-Man (2012), Life of Pi (2012), Jurassic World (2015) and Inferno (2016).
In 2014, Irfan Khan ( 7 January 1967 – 29 April 2020) appeared in Gunday, which was a moderate box office success. He also made guest appearances in the films The Xpose and Haider, playing an important role in the latter. In 2015, he played the lead role in the film Piku alongside Deepika Padukone and Amitabh Bachchan, he also appeared in the acclaimed thriller Talvar in which his performance was praised. He appeared in Jazbaa in October 2015 alongside Aishwarya Rai which was very well received by critics.
In 2017, Khan appeared in two films, Hindi Medium which was commercially and critically successful. Khan's portrayal as Raj Batra in Hindi Medium earned him several accolades, one of which was the Filmfare Award for Best Actor.
In 2018, Khan appeared in Karwan, he also appeared in Blackmail opposite Kirti Kulhari, the same year. His last film appearance was in Angrezi Medium, directed by Homi Adajania, which was released on 13 March 2020
He died at a young age of 53 on 29th April 2020